Scott A. Barros, PhD, DABT Sr. Scientist, Toxicology What is an Aptamer? Aptamer Structure Medicinal Chemistry Process Increased plasma stability Increased affinity ...
Date added: October 30, 2011 - Views: 118
Flavin mononucleotide RFN aptamer Genetic Control Mechanisms Tom Cech, Nature (2004) 428: 263-264. Genetic Control Mechanisms - RIBOSWITCHES Tom Cech, Nature ...
Date added: October 31, 2011 - Views: 63
Impact Aptamer recognition elements enable detection of ... Institute for Collaborative Biotechnologies University of California at Santa Barbara working with ...
Date added: October 12, 2011 - Views: 57
030213-141013 PubMed: aptamer + review = 37 refs (370 Total) Mode of Application: 1: Yadav SK, Chandra P, Goyal RN, Shim YB. A review on determination of steroids in ...
Date added: July 12, 2015 - Views: 1
Factor IXa Inhibition Aptamer Technology Overview and First Results with RB006/RB007 Mauricio G. Cohen, MD Associate Professor of Medicine Director, Cardiac Cath Lab
Date added: November 8, 2011 - Views: 39
... adaptamer linker sequences can basepair to aptamer regions or to self Designing adaptamer linkers Program ... clones originally received in pET22 ...
Date added: May 13, 2013 - Views: 3
Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Kenzo Maehashi, Taiji Katsura, Kagan Kerman, Yuzuru Takamura,
Date added: November 30, 2012 - Views: 15
Supplementary Figure 1 A B 7.93 PEG-Aptamer 500 400 9.66 NH2-Aptamer 300 200 Absorbance (mAU) 100 7.93 PEG-Aptamer 300 250 200 150 100 50 5.0 10.0 15.0 20.0 25.0 ml
Date added: November 9, 2014 - Views: 1
Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Author: Ryan Yang Last modified by: Ryan Yang Created Date:
Date added: May 11, 2013 - Views: 10
Title: BIOSENSOR (General principles and applications) Author: Jayanti Tokas, Rubina Begum, Shalini Jain, Hariom Yadav Last modified by: Eugene Created Date
Date added: September 17, 2011 - Views: 443
The atomic structure reveals six bound Mg(II) ions in the folded M box aptamer that are implicated in this regulatory transition.
Date added: July 1, 2015 - Views: 1
Inhibition of tumour growth in mice treated with PSMA aptamer targeted Upf2 and Smg1 siRNAs. F Pastor et al. Nature 465, 227-230 (2010) doi:10.1038/nature08999
Date added: January 25, 2015 - Views: 1
Specific Resources. blood, urine, biopsy & autopsy samples, clinical tests & information. intravital. imaging, flow . cytometry, mAb / aptamer. production, HTP tests
Date added: February 5, 2015 - Views: 4
Interaction energy results correlate to binding affinity of Theophylline aptamer Theophylline >> Theobromine > Caffeine C22 is a discriminating factor
Date added: October 18, 2015 - Views: 1
Aptamer antagonist of tissue factor pathway inhibitor. Improved thrombin generation in plasma from subjects with FVIII deficiency. ... PowerPoint Presentation
Date added: April 19, 2013 - Views: 23
... G-3-TNPO3 chimera combines G-3 aptamer function with TNPO3 gene silencing, resulting in a dual inhibitory effect on HIV-1 entry and replication.
Date added: August 12, 2015 - Views: 1
Evaluation of a radiolabeled binding aptamer ([99mTc]-TTA1) specific for extracellular matrix protein tenascin-C, verses a radiolabeled nonbinding aptamer, in mice ...
Date added: November 5, 2014 - Views: 1
Scheme 1.6 X-ray structure of RNA aptamer complex with 5’-adenosine monophosphate (AMP) guest. Supplementary information for .
Date added: July 28, 2015 - Views: 1
RNA aptamer . Factor IXa inhibitor. Controlling agent. Active. Specific . Immediate. Titratable. Prior studies. Phase 1a, 1b, 1c (n = 174) Phase 2a PCI (n = 26)
Date added: November 10, 2011 - Views: 11
... Intracellular Lung Tarceva, Iressa Aptamer Cell Surface, Intracellular Renal, Lung AS1411 (in dev.) Peptide Cell Surface, Intracellular Breast, Thyroid RGD ...
Date added: November 11, 2011 - Views: 32
Soontornworajit, B., Zhou, J., Zhang, Z., Wang, Y. Aptamer-functionalized in situ injectable hydrogel for controlled protein release. Biomacromolecules. 2010; ...
Date added: September 9, 2014 - Views: 2
CTA/IND. Drug resistant bacterial infection BB5000. TineaPedis. BB2603. Peptide aptamer. Inflammatory bowel disease BB0109 . Peptide therapeutic. Launch. Skin care
Date added: September 9, 2014 - Views: 1
(Left) A fluorescence micrograph of Gold nanostars (AuNS) loaded with high densities of nucleolin-specific DNA aptamer (Apt-AuNS). (Right) ...
Date added: June 24, 2015 - Views: 1
Chap. 6 – Antigen-Antibody interactions Author: dbuckalew Last modified by: dbuckalew Created Date: 3/9/2004 8:40:49 PM Document presentation format: On-screen Show
Date added: November 2, 2011 - Views: 102
aptamer. fragments. Anal Method . 2011; 3:59-61. ... Lead: 100 ppt (2 orders of magnitude below the EPA standard limit) 2-3 orders of magnitude. Small molecules. 7 nM
Date added: June 10, 2013 - Views: 21
PLGA PEG + NH2 Add to water + EDC/NHS Drug Nanoprecipitation Aptamer Nanoparticle Targeted nanoparticle Nanoparticle Farokhzad, et al. PNAS (2006) ...
Date added: November 25, 2011 - Views: 42
Cell Surface Targeting: The week of waiting 8/14/06
Date added: August 4, 2013 - Views: 3
Study of the interaction between the porphyrin TmPyP4 and the Thrombin Binding Aptamer (TBA) G-quadruplex ... guanine3 guanine4 pKa = 10,5 0,1 TmPyP4 Melting
Date added: March 7, 2012 - Views: 20
... Design and characterization of antiswitches in E. coli. Outline for presentation Background Antiswitches Aptamer PowerPoint Presentation Ribozymes ...
Date added: May 29, 2013 - Views: 8
Use a naturally occurring or synthetic analog of a molecule (antibody, aptamer, etc.) that has a high affinity to a specific ligand (or analyte) IMMUNOASSAYS.
Date added: August 10, 2015 - Views: 1
CU Boulder Research, Scholarly Activity, and Creative Works GSAC April 30, 2010 Russ Moore, Interim VC Research Research & Scholarly Works Remarkable record of ...
Date added: August 1, 2013 - Views: 386
Theophylline-binding aptamer (B) (C) Luciferase Activity (% of Control) Luciferase Activity (% of Control) ...
Date added: April 18, 2015 - Views: 1
Chapter 6. Synthetic Receptors for Nucleosides and Nucleotides. JinrokOh,a Hyun-Woo Rhee,b and Jong-In Honga* a Department of Chemistry, Seoul National University ...
Date added: August 29, 2015 - Views: 1
Research focus on riboswitches Bioinformatics Searching for riboswitches in eukaryotes by their aptamer Sequence is not enough, need structure considerations!
Date added: August 31, 2013 - Views: 1
... (Vienna RNA) Aptamer/Antiterminator/Terminator competition Evidence for natural selection of reliably folding sequences Probability of no selection P ~ 0.01 ...
Date added: May 11, 2013 - Views: 11
... # 1st Spring Vertebrate Interactome Mapping Scott Stevens Molecular Biology 35 2006 Aptamer Selection Andy Ellington Biochemistry / Biology 35 2006 ...
Date added: September 21, 2013 - Views: 5
Title: Targeting IL-4 and IL-13 Author: Paul O Last modified by: Andrea Created Date: 9/16/2009 3:31:03 PM Document presentation format: Presentazione su schermo (4:3)
Date added: October 22, 2011 - Views: 8
Terminator Aptamer Research focus on riboswitches Bioinformatics Without TPP What are Riboswitches? Anti-terminator Aptamer Vitamin B1 biosynthesis in bacteria: ...
Date added: July 30, 2013 - Views: 5
... Binds specific ligand Theophylline Theophylline aptamer Caffeine Synthesize de novo Terminator + YFP Add antiswitch On Off ‘Off’ antiswitch ‘On ...
Date added: May 10, 2013 - Views: 3
Applications of Molecular Imprinting Technology to Immunoassays Roger L. Bertholf, Ph.D. Associate Professor of Pathology University of Florida Health Science Center ...
Date added: February 4, 2012 - Views: 33
Inhibition of human and pig thrombin by a high-affinity nuclease-resistant RNA aptamer Rebekah White, M.D., Chris Rusconi, Ph.D., Maureane Hoffman, M.D., Ph.D., Jeff ...
Date added: November 12, 2015 - Views: 1
... Free Energy Less per atom energy Simple accounting scheme (2nd Structures) Open Structure w/ size NA aptamer NA unstructured w/o ligand.
Date added: September 14, 2013 - Views: 1
Ontario Research Fund Research Excellence Round 6 September 2011 Introduction The Ontario Research Fund Research Excellence (ORF-RE) program promotes research ...
Date added: August 17, 2013 - Views: 321
... 8% -> 96% REGULATION OF GENE EXPRESSION ANTISENSE STRATEGY interaction with RNA ANTIGENE STRATEGY interaction with DNA APTAMER STRATEGY interaction with ...
Date added: December 21, 2013 - Views: 4
Riboswitches contain an aptamer (RNA binding) domain & expression platform Riboswitches J.K. Soukup and G.A. Soukup, Curr. Opin. Struct. Biol. (2004) 14: 344-349.
Date added: September 21, 2014 - Views: 1
EUROpean network of transnational collaborative RTD projects in the field of NANOMEDicine
Date added: May 2, 2013 - Views: 18
EUROpean network of transnational collaborative RTD projects in the field of NANOMEDicine * www.euronanomed.net
Date added: June 17, 2012 - Views: 43
a 28-base ribonucleic acid aptamer covalently linked to two branched 20-kD polyethylene glycol . bind and block the activity of extracellular VEGF 165.
Date added: May 8, 2013 - Views: 6
Aptamer Database. Nucl. Acids. Res. 2004 32: D95-D100. [Abstract] [FREE Full Text] ...
Date added: April 19, 2014 - Views: 8